In 2017, McAnulty matched volunteer scientists with teachers and classrooms by hand using a Google spreadsheet, which she shared repeatedly on Twitter and Tumblr. McAnulty was concerned that scientists were portrayed in media as "cold and calculating" and aimed to connect people with scientists through video conferencing to dispel those stereotypes, and to "get people trusting scientists again". Inspiration for the program came from the growing distrust of scientists and the rise of anti-intellectualism in US society.
Sarah McAnulty came up with the idea for Skype a Scientist in 2016 while she was a graduate student in molecular and cell biology at the University of Connecticut in Storrs.
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